IJMH – Volume 4 Issue 1 Paper 1

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COLOSTRUM-MIRACULOUS FLUID

Author’s Name : Dr Shalini Sood | Dr Archna Gupta

Volume 04 Issue 01  Year 2017  ISSN No:  2349-7289  Page no: 1-5

12

Abstract:

Colostrum known colloquially as beestings, bisnings or first milk is a form of milk produced by the mammary glands of mammals (including humans) in late pregnancy. Droplets of Colostrum expressed from the breast of a 40-weeks pregnant woman. Newborns have very immature digestive systems, and Colostrum delivers its nutrients in a very concentrated low-volume form. It has a mild laxative effect, encouraging the passing of the baby’s first stool, which is called Meconium. This clears excess bilirubin, a waste-product of dead red blood cells, which is produced in large quantities at birth due to blood volume reduction from the infant’s body and helps prevent jaundice. Colostrum is known to contain immune cells (as lymphocytes) and many antibodies such as IgA, IgG, and IgM. These are some of the components of the adaptive immune system. Other immune components of Colostrum include the major components of the innate immune system, such aslactoferrin, lysozyme, lactoperoxidase, complement, and proline rich polypeptides. A number of cytokines (small messenger peptides that control the functioning of the immune system) are found in Colostrum. Colostrum is very rich in proteins, vitamin A, and sodium chloride, but contains lower amounts of carbohydrates, lipids, and potassium than mature milk. The most pertinent bioactive components in colostrum are growth factors and antimicrobial factors. The antibodies in colostrum provide passive immunity, while growth factors stimulate the development of the gut. They are passed to the neonate and provide the first protection against pathogens.

Keywords:

Colostrum, Miraculous Fluid, Infant Booster, Immuno-regulator, First line of Defense, Bioactive Component,Pathogen Killer, Antimicrobial component

References:

  1. Gottstein, Michael. Colostrum is vital ingredient to keep newborn lambs alive. Irish Independent. 3 March 2009.
  2. Peter Bird, Northamptonshire ACRE ‘Village Voices’ oral history recordings, Northamptonshire ACRE and Northamptonshire County Archives.
  3. Meyer, A. M., J. J. Reed, T. L. Neville and J. F. Thorson. 2011. Nutritional plane and selenium supply during gestation affect yield and nutrient composition of colostrum and milk in primiparous ewes. USDA Agric. Res. Serv./U. Nebraska, Lincoln. Paper 716.
  4. Pearl, J. N.; Edwards, R. A.; Donaldson, E. (1972). “The yield and composition of the milk of Finnish Landrace x Blackface ewes: 1. Ewes and lambs raised indoors”. J. Agr. Sci. 79: 303–313.
  5. Or-Rashid, M. M.; Fisher, R.; Karrow, N.; AlZahal, O.; McBride, B. W. (2010). “Fatty acid profile of colostrum and milk of ewes supplemented with fish meal and the subsequent plasma fatty acid status of their lambs”. J. Anim. Sci. 88: 2092–2102. doi:10.2527/jas.2009-1895.
  6. Csapo, J.; Stefler, J.; Martin, T. G.; Makray, S.; Sz (1995). “Composition of mares’ colostrum and milk. Fat content, fatty acid composition and vitamin content”. Int. Dairy J. 5: 393–402. doi:10.1016/0958-6946(94)00008-d.
  7. Pikul, J.; Wojtowski, J.; Dankow, R.; Kuckzynsk, B.; Lojek, J. (2008). “Fat content and fatty acids profile of colostrum and milk of primitive Konik horses (Equus caballus gmelini Ant.) during six months of lactation”. J. Dairy Res. 75: 302–309. doi:10.1017/s0022029908003336.
  8. Zhang, H.; Yao, J.; Zhao, D.; Liu, H.; Li, J. (2005). “Changes in chemical compostion of Alxa Bactrian camel milk during lactation”. J. Dairy Sci. 88: 3402–3410.doi:10.3168/jds.s0022-0302(05)73024-1.
  9. Saint, L.; Smith, M.; Hartmann, P. E. (1984). “The yield and nutrient content of colostrum and milk of women from giving birth to 1 month post-partum”. Br. J. Nutr. 52: 87–95.doi:10.1079/bjn19840074.
  10. Bertotto, A; Castellucci, G; Fabietti, G; Scalise, F; Vaccaro, R (1 November 1990). “Lymphocytes bearing the T cell receptor gamma delta in human breast milk”. Arch Dis Child. 65: 1274–5. doi:10.1136/adc.65.11.1274-a.PMC 1792611 . PMID 2147370.
  11. Weaver, L. T., Wadd, N., Taylor, C. E., Greenwell, J. and Toms, G. L. (June 1991). “The ontogeny of serum IgA in the newborn”. Pediatric Allergy and Immunology. 2 (2): 72–75.doi:10.1111/j.1399-3038.1991.tb00185.x.
  12. Groves, ML (1960). “The isolation of a red protein from milk”. Journal of the American Chemical Society. 82 (13): 3345–3360. doi:10.1021/ja01498a029.
  13. Paulík S, Slanina L, Polácek M; Slanina; Polácek (January 1985). “[Lysozyme in the colostrum and blood of calves and dairy cows]”. Vet Med (Praha) (in Slovak). 30 (1): 21–8.PMID 3918380.
  14. Reiter B (1978). “The lactoperoxidase-thiocyanate-hydrogen peroxide antibacterium system”. Ciba Found. Symp. (65): 285–94. PMID 225143.
  15. Brock, JH; et al. (1975). “Bactericidal and hemolytic activity of complement in bovine colostrum and serum: effect of proteolytic enzymes and ethylene glycol tetraacetic acid (EGTA)”. Annales d’Immunologie. 126C (4): 439–451.
  16. Zabłocka A, Janusz M, Rybka K, Wirkus-Romanowska I, Kupryszewski G, Lisowski J; Janusz; Rybka; Wirkus-Romanowska; Kupryszewski; Lisowski (2001). “Cytokine-inducing activity of a proline-rich polypeptide complex (PRP) from ovine colostrum and its active nonapeptide fragment analogs”. Eur. Cytokine Netw. 12 (3): 462–7.PMID 11566627.
  17. Hagiwara K, Kataoka S, Yamanaka H, Kirisawa R, Iwai H; Kataoka; Yamanaka; Kirisawa; Iwai (October 2000). “Detection of cytokines in bovine colostrum”. Vet. Immunol. Immunopathol. 76 (3–4): 183–90. doi:10.1016/S0165-2427(00)00213-0. PMID 11044552.
  18. Rudloff HE, Schmalstieg FC, Mushtaha AA, Palkowetz KH, Liu SK, Goldman AS; Schmalstieg Jr; Mushtaha; Palkowetz; Liu; Goldman (January 1992). “Tumor necrosis factor-alpha in human milk”. Pediatr. Res. 31 (1): 29–33.doi:10.1203/00006450-199201000-00005.PMID 1375729.
  19. Maheshwari A, Christensen RD, Calhoun DA; Christensen; Calhoun (November 2003). “ELR+ CXC chemokines in human milk”. Cytokine. 24 (3): 91–102.doi:10.1016/j.cyto.2003.07.002. PMID 14581003.
  20. Xu RJ (1996). “Development of the newborn GI tract and its relation to colostrum/milk intake: a review”. Reprod. Fertil. Dev. 8 (1): 35–48. doi:10.1071/RD9960035.PMID 8713721.
  21. O’Dell SD, Day IN; Day (July 1998). “Insulin-like growth factor II (IGF-II)”. Int. J. Biochem. Cell Biol. 30 (7): 767–71.doi:10.1016/S1357-2725(98)00048-X. PMID 9722981.
  22. Okada M, Ohmura E, Kamiya Y, et al. (1991). “Transforming growth factor (TGF)-alpha in human milk”. Life Sci. 48 (12): 1151–6. doi:10.1016/0024-3205(91)90452-H.PMID 2002746.
  23. Saito S, Yoshida M, Ichijo M, Ishizaka S, Tsujii T; Yoshida; Ichijo; Ishizaka; Tsujii (October 1993). “Transforming growth factor-beta (TGF-beta) in human milk”. Clin. Exp. Immunol. 94 (1): 220–4. doi:10.1111/j.1365-2249.1993.tb06004.x. PMC 1534356 . PMID 8403511.
  24. Tokuyama Y, Tokuyama H; Tokuyama (February 1993). “Purification and identification of TGF-beta 2-related growth factor from bovine colostrum”. J. Dairy Res. 60 (1): 99–109.doi:10.1017/S0022029900027382. PMID 8436667.
  25. Hironaka, T; et al. (1997). “Identification and partial purification of a basic fibroblast growth factor-like growth factor derived from bovine colostrum”. Journal of Dairy Science. 80 (3): 488–495. doi:10.3168/jds.s0022-0302(97)75961-7.
  26. Xiao X, Xiong A, Chen X, Mao X, Zhou X; Xiong; Chen; Mao; Zhou (March 2002). “Epidermal growth factor concentrations in human milk, cow’s milk and cow’s milk-based infant formulas”. Chin. Med. J. 115 (3): 451–4.PMID 11940387.
  27. Playford RJ, Macdonald CE, Johnson WS; MacDonald; Johnson (July 2000). “Colostrum and milk-derived peptide growth factors for the treatment of gastrointestinal disorders”. Am. J. Clin. Nutr. 72 (1): 5–14.PMID 10871554.
  28. Vuorela P, Andersson S, Carpén O, Ylikorkala O, Halmesmäki E; Andersson; Carpén; Ylikorkala; Halmesmäki (November 2000). “Unbound vascular endothelial growth factor and its receptors in breast, human milk, and newborn intestine”. Am. J. Clin. Nutr. 72 (5): 1196–201.PMID 11063449.
  29. Flidel-Rimon O, Roth P; Roth (November 1997). “Effects of milk-borne colony stimulating factor-1 on circulating growth factor levels in the newborn infant”. J. Pediatr. 131(5): 748–50. doi:10.1016/S0022-3476(97)70105-7.PMID 9403658.
  30. Donovan, S.M. and J. Odle (1994) Growth factors in milk as mediators of infant development. Annual Review of Nutrition 14, 147-167.
  31. Elson C.O. and K.W. Beagley (1994) Cytokines and immune mediators. In: Johnson L.R. Physiology of the gastro-intestinal tract. 3rd ed. New York, USA: Raven, 243-266.
  32. Harmsen M.C., et al. (1995) Antiviral effects of plasma and milk proteins: Lactoferrin shows potent activity against both human immunodeficiency virus and human cytomegalo-virus replication in vitro. Journal of Infectious Diseases 172, 380-388.
  33. Hill I.R. and P. Porter (1974) Studies of bactericidal activity to Escherichia coli of porcine serum and colostral immunoglobulins and the role of lysozyme with secretory IgA. Immunology 26, 1239-1250.
  34. Hulea S.A., et al. (1989) Interaction of lactoperoxidase with enzymes and immunoglobulins in bovine milk. Biochem. Int. 19, 1173-1181.
  35. Kussendrager K.D. and A.C.M. van Hooijdonk (2000) Lactoperoxidase: physico-chemical properties, occurrence, mechanism of action and applications. Br. J. Nutr. 84(S1), S19-S25.
  36. Shams, D. (1994) Growth factors in milk. Endocrine Regulations 28, 3-8.
  37. Viljoen M. (1995) Lactoferrin: a general review. Haematologica 80, 252-267.
  38. Yamauchi K., et al. (1993) Antibacterial activity of lactoferrin and a pepsin-derived lactoferrin peptide fragment. Infect. Immun. 61, 719-728.
  39. Raymond J Playford, Christopher E Macdonald and Wendy S Johnson. Colostrum and milk-derived peptide growth factors for the treatment of gastrointestinal disorders. Am J ClinNutr; 72:5–14 (2000).
  40. AFO.Kaducu, S.A.Okia, G.Upenytho, L.Elfstrand and C.-H. Florén. Effect of bovine colostrum-based food supplement in the treatment of HIV-associated diarrhea in Northern Uganda: a randomized controlled trial. Indian J Gastroenterology 30(6):270–276 (2011).
  41. Schwade, S. Insulin-like growth factors. Muscle &Fitness. (1992).
  42. JolantaArtym, Michal Zimecki and Marian L. Kruzel. Effect OfLactoferrin On the methotrexate-induced suppression of the cellular and humoral immune response in mice. Anticancer research; 24: 3831-3836 (2004).
  43. Michelle Chen &Chinh Huynh. Weapons of targeted destruction. http://www.odec.ca/projects/2008/huyn8c2/CLA.html.
  44. Macdonald, Helen B. Conjugated linoleic acid and disease prevention: A review of current knowledge. Journal of American college of nutrition; 10(2):111s-118s (2000)
  45. Oona M, Rigo T, Maaroos H, et al. Helicobacter pylori in children with abdominal complaints: has immune colostrum some influence on gastritis? AlpeAdria Microbiology Journal; 6:49-57(1997).
  46. F. O. Kaducu, S, A. Okia  G, Upenytho, L. Elfstrand and C.-H. Florén. Effect of bovine colostrum-based food supplement in the treatment of HIV-associated diarrhea in Northern Uganda: a randomized controlled trial. Indian J Gastroenterol ; 30(6):270–276 (2011).
  47. Claes-Henrik Flore ´N, Sonny Chinenye, Lidia Elfstrand, ConnyHagman and IngemarIhse. ColoPlus, a new product based on bovine colostrum, alleviates HIV-associated diarrhea. Scandinavian Journal of Gastroenterology; 41: 682 – 686 (2006).
  48. W Otto et al.Randomized control trial using a tablet formulation of hyperimmune bovine colostrum to prevent diarrhea caused by enterotoxigenic E Coli in volunteers. Journal OF Gastroenterology(2011).
  49. Brinkworth GD, Buckley JD, Bourdon PC, et al. Oral bovine colostrum supplementation enhances buffer capacity but not rowing performance in elite female rowers. Int J Sport Nutrition Exercise Metabolism;12:349-365 (2002).
  50. Coombs JS, et al. Dose effects of oral bovine colostrum on physical work capacity in cyclists. Medicine Science Sports Exercise 34(7): 1184-8 (2002).